Abstract

Research Article

Renal function effects of FDS, a saponin isolated from Filicium decipiens seeds: Biochemical and Histopathological studies

Romero MP Brandao-Costa*, Juanize Matias S Batistaa, Thiago Pajeu Nascimento and Ana LF Porto

Published: 31 October, 2019 | Volume 3 - Issue 3 | Pages: 107-110

Physicochemical and pharmacological studies indicated that Filicium decipiens seeds contained various specialized metabolites, including saponins. The aim of this work is to reveal the nephrotoxicity of FDS, a saponin isolated from Filicium decipiens seeds on male Wistar rats histopathological and biochemical parameters. Rats were submitted to oral ingestion of FDS (6.0 mg/kg) and crude extract (120.0 mg/kg) and were observed high levels of urea and creatinine in blood analyses of all animals followed by an acute renal failure by glomerular retraction. In the present study, FDS and crude extract when administered in Wistar rats induced an increase of serum levels of Urea and Creatinine, biochemical markers of kidney function. Table 1 shows Urea concentration at Test group with FDS (54.3 ± 1.80 mg/ml) and Test group with crude extract (49.7 ± 2.00 mg/ml), were 47% and 34.7% higher, respectively, when compared to control group (36.9 ± 2.00 mg/ml), and Creatinine at the test group with FDS (2.1 ± 0.03 mg/ml) and test group with crude extract (1.6 ± 0.09 mg/ml) presented a value 3.5 and 2.8 times higher, respectively, than control (0.6 ± 0.08 mg/ml). Based on these results, our data demonstrate a significant effect in renal function of rats treated with F. decipiens saponin.

Read Full Article HTML DOI: 10.29328/journal.jpsp.1001040 Cite this Article Read Full Article PDF

Keywords:

Nephrotoxicity; Renal failure; Saponin; Biological effect; Biochemical analysis

References

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