Antiviral RNAi mediated Plant defense versus its suppression by viruses

Main Article Content

Dinesh Gupta
Sunil Kumar

Abstract

The age-old battle between plants and viruses has many twists and turns. Plants acquired the RNAi factors to checkmate the viruses and the viruses encode VSRs to defeat RNAi for their own survival. Plants designed mechanisms to neutralize the toxic effects of VSRs and the viruses, in their turn, use host microRNAs to strengthen their infection processes. The infightings between these two entities will take different shapes with prolonged evolution and accordingly the researchers will dig these novel forms of duels not only to throw lights in the involved mechanisms but also to manipulate various antiviral strategies. Some of the research courses that might come up in the immediate future are discussed.

Article Details

Gupta, D., & Mukherjee, S. K. (2019). Antiviral RNAi mediated Plant defense versus its suppression by viruses. Journal of Plant Science and Phytopathology, 3(1), 001–008. https://doi.org/10.29328/journal.jpsp.1001025
Commentaries

Copyright (c) 2019 Karaca M, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The Journal of Plant Science and Phytopathology is committed in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. In order to use the Open Access paradigm to the maximum extent in true terms as free of charge online access along with usage right, we grant usage rights through the use of specific Creative Commons license.

License: Copyright © 2017 - 2025 | Creative Commons License Open Access by Journal of Plant Science and Phytopathology is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at Heighten Science Publications Inc.

With this license, the authors are allowed that after publishing with the journal, they can share their research by posting a free draft copy of their article to any repository or website.

Compliance 'CC BY' license helps in:

Permission to read and download
Permission to display in a repository
Permission to translate
Commercial uses of manuscript

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license. 

Agrawal N, Dasaradhi PV, Mohmmed A, Malhotra P, Bhatnagar RK, et al. RNA interference: biology: mechanism: and applications. Micro Mol Biol Rev. 2003; 67: 657-685. Ref.: https://goo.gl/yZVjzk

Koonin EV, Dolja VV, Krupovic M. Origins and evolution of viruses of eukaryotes: The ultimate modularity. Virol. 2015; 479-480: 2-25. Ref.: https://goo.gl/wsJprG

Ma A, Mondragón RJ. Rich-Cores in Networks. PLoS One. 2015; 10: 1-13. Ref.: https://goo.gl/5iN9iU

Rajewsky, Nikolaus, Jurga, Stefan, Barciszewski. In Plant Epigenetics. RNA Tech. 199-230. Ref.: https://goo.gl/twwyMH

Yang Z, Li Y. Dissection of RNAi-based antiviral immunity in plants. Curr Opin Virol.2018; 32: 88-99. Ref.: https://goo.gl/eNnTC8

Llave C. Virus-derived small interfering RNAs at the core of plant-virus interactions.Trends Plant Sci. 2010; 15: 701-707. Ref.: https://goo.gl/HbDbgP

Wang XB, Jovel J, Udomporn P, Wang Y, Wu Q, et al. The 21-Nucleotide, but Not 22-Nucleotide, Viral Secondary Small Interfering RNAs Direct Potent Antiviral Defense by Two Cooperative Argonautes in Arabidopsis thaliana [W][OA]. Plant Cell. 2011; 23: 1625-1638. Ref.: https://goo.gl/qFWGKq

Brosseau C, El Oirdi M, Adurogbangba A, Ma X, Moffett P. Antiviral Defense Involves AGO4 in an Arabidopsis–Potexvirus Interaction. Mol Plant-Microbe Int. 2016; 29: 878-888. Ref.: https://goo.gl/vyJsNT

Hort Res. 2018; 5: 62-75. Ref.:

Mirian SJ, Mohammadi AR, Karimi G, Nia KI, Motamedi G, et al. Survey on helminthic and protozoan contaminations in alimentary canal of ostrich at Tehran Province slaughterhouses. Viruses. 9: 256-276. Ref.: https://goo.gl/fi3gct

Taochy C, Gursanscky NR, Cao J, Fletcher SJ, Dressel U, et al. A Genetic Screen for Impaired Systemic RNAi Highlights the Crucial Role of DICER-LIKE 2. Plant Physiol. 2017; 175: 1424-1437. Ref.: https://goo.gl/6dd2ou

Qin C, Li B, Fan Y, Zhang X, Yu Z, et al. Roles of Dicer-Like Proteins 2 and 4 in Intra- and Intercellular Antiviral Silencing. Plant Physiol. 2017; 174: 1067-1081. Ref.: https://goo.gl/fXhm5m

Guo Z, Lu J, Wang X, Zhan B, Li W, et al. Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis. Proc Acad Natl Sci (USA). 2017; 114: 1377-1382. Ref.: https://goo.gl/VzaYr8

Guo Z, Wang XB, Wang Y, Li WX, Gal-On A, et al. Identification of a New Host Factor Required for Antiviral RNAi and Amplification of Viral siRNAs. Plant Physiol. 2017; 176: 1587-1597. Ref.: https://goo.gl/qv7qfL

Simón-Mateo C, García JA. MicroRNA-guided processing impairs Plum pox virus replication, but the virus readily evolves to escape this silencing mechanism. J Virol. 2006; 80: 2429-2436. Ref.: https://goo.gl/TLb9on

Deng P, Muhammad S, Cao M, Wu L. Biogenesis and regulatory hierarchy of phased small interfering RNAs in plants. Plant Biotech J. 2018; 16: 965-975. Ref.: https://goo.gl/6y4BqU

Bivalkar-Mehla S, Vakharia J, Mehla R, Abreha M, Kanwar JR, et al. Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system. Virus Res. 2011; 155: 1-9. Ref.: https://goo.gl/ovBczc

Zhao JH, Hua CL, Fang YY, Guo HS. The dual edge of RNA silencing suppressors in the virus-host interactions. Curr Opin Virol. 2016; 17: 39-44. Ref.: https://goo.gl/QkS6Hz

Csorba T, Kontra L, Burgyán J. Viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence. Virol. 2015; 479-480, 85-103. Ref.: https://goo.gl/mNuQoY

Pérez-Cañamás M, Hernández C. Key importance of small RNA binding for the activity of a glycine-tryptophan (GW) motif-containing viral suppressor of RNA silencing. J Biol Chem. 2015; 290: 3106-3120. Ref.: https://goo.gl/Ankwiw

Pertermann R, Tamilarasan S, Gursinsky T, Gambino G, Schuck J, et al. A Viral Suppressor Modulates the Plant Immune Response Early in Infection by Regulating MicroRNA Activity. mBio. 2018’ 9: e00419-18. Ref.: https://goo.gl/SL7tWw

Incarbone M, Zimmermann A, Hammann P, Erhardt M, Michel F, et al. Neutralization of mobile antiviral small RNA through peroxisomal import. Nat Plant. 2017; 3: 17094. Ref.: https://goo.gl/oL3w2K

Li F, Wang A. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLos Pathog. 2018; 14: e1007228. Ref.: https://goo.gl/anRxTq

Pumplin N, Voinnet O. RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence. Nat Rev (Microbiol). 2013; 11: 745-760. Ref.: https://goo.gl/6yYLYd

Chen L, Yan Z, Xia Z, Cheng Y, Jiao Z, et al. A Violaxanthin Deepoxidase Interacts with a Viral Suppressor of RNA Silencing to Inhibit Virus Amplification. Plant Physiol. 2017; 175:1774-1794. Ref.: https://goo.gl/sedWUc

Shen Q, Hu T, Bao M, Cao L, Zhang H, et al. Tobacco RING E3 Ligase NtRFP1 Mediates Ubiquitination and Proteasomal Degradation of a Geminivirus-Encoded βC1. Mo Plant. 2016; 9: 911-925. Ref.: https://goo.gl/4HSfhS

Jeon EJ, Tadamura K, Murakami T, Inaba JI, Kim BM, et al. rgs-CaM Detects and Counteracts Viral RNA Silencing Suppressors in Plant Immune Priming. J Virol. 2017; 91-e00761-17. Ref.: https://goo.gl/D5UYNM

Várallyay E, Válóczi A, Agyi A, Burgyán J, Havelda Z. Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation. EMBO J. 2010; 29: 3507-3519. Ref.: https://goo.gl/LXHHCa

Zheng L, Zhang C, Shi C, Yang Z, Wang Y, et al. Rice stripe virus NS3 protein regulates primary miRNA processing through association with the miRNA biogenesis factor OsDRB1 and facilitates virus infection in rice. PLos Pathog. 2017; 13: e1006662. Ref.: https://goo.gl/uxY2XZ

Scientific Repts. 2016; 6: 20167-20180.

Feng J, Liu S, Wang M, Lang Q, Jin C. Identification of microRNAs and their targets in tomato infected with Cucumber mosaic virus based on deep sequencing. Planta. 2014; 240: 1335-1352. Ref.: https://goo.gl/nLh15N

Iki T, Cléry A, Bologna NG, Sarazin A, Brosnan CA, et al. Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants. Mol Plant. 2018; 11: 1008-1023. Ref.: https://goo.gl/xknqL2

Várallyay E, Havelda Z. Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level. Mol Plant Pathol. 2013; 14: 567-575. Ref.: https://goo.gl/aqxqUd

Noman A, Aqeel M, Deng J, Khalid N, Sanaullah T, et al. Biotechnological Advancements for Improving Floral Attributes in Ornamental Plants. Front Plant Sci. 2017; 8: 1760-1769. Ref.: https://goo.gl/x7nhm6

Honda T, Yamamoto K, Yo A, Takarada Y, Shibata H. PCR primer to detect cholera toxin-producing Vibrio cholera. ELIFE: Microbiol and Infect. diseses/ Plant Biol. 2015; 4: e05733. Ref.: https://goo.gl/8jH14n

Kravchik M, Sunkar R, Damodharan S, Stav R, Zohar M, et al. Global and local perturbation of the tomato microRNA pathway by a trans-activated DICER-LIKE 1 mutant. J Exp Bot. 2014; 65: 725-739. Ref.: https://goo.gl/xcb58y

Wang Z, Hardcastle TJ, Canto Pastor A, Yip WH, Tang S, et al. A novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses. Genes and Dev. 2018; 32: 1155-1160. Ref.: https://goo.gl/Jrii6P

Virology J. 2010; 7: 281-296.

Zhang C, Ding Z, Wu K, Yang L, Li Y, et al. Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice. Mol Plant. 2016; 9: 1302-1314. Ref.: https://goo.gl/TCkmMe

Cillo F, Mascia T, Pasciuto MM, Gallitelli D. Differential effects of mild and severe Cucumber mosaic virus strains in the perturbation of MicroRNA-regulated gene expression in tomato map to the 3' sequence of RNA 2. Mol Plant-Microbe Int. 2009; 22: 1239-1249. Ref.: https://goo.gl/bgTdAi

Obbard DJ, Gordon KH, Buck AH, Jiggins FM. The evolution of RNAi as a defence against viruses and transposable elements. Phil Trans R Soc B. 2009; 364: 99-115. Ref.: https://goo.gl/3CEeFo

Aguado LC, Schmid S, May J, Sabin LR, Panis M, et al. RNase III nucleases from diverse kingdoms serve as antiviral effectors. Nature. 2017; 547: 114-117. Ref.: https://goo.gl/HoRmYN

Vazquez F, Blevins T, Ailhas J, Boller T, Meins F, Jr. Evolution of Arabidopsis MIR genes generates novel microRNA classes. Nucl Ac Res. 2008; 36: 6429-6438. Ref.: https://goo.gl/bWbgvQ

Ying XB, Dong L, Zhu H, Duan CG, Du QS, et al. RNA-Dependent RNA Polymerase 1 from Nicotiana tabacum Suppresses RNA Silencing and Enhances Viral Infection in Nicotiana benthamiana. Plant Cell. 2010; 22: 1358-1372. Ref.: https://goo.gl/snkReA

Ishibashi K, Kezuka Y, Kobayashi C, Kato M, Inoue T, et al. Structural basis for the recognition–evasion arms race between Tomato mosaic virus and the resistance gene Tm-1. Proc Natl Acd Sc. U S A. 2014; 111: E3486-E3495. Ref.: https://goo.gl/vjZTfo